Al Mayadeen English

  • Ar
  • Es
  • x
Al Mayadeen English

Slogan

  • News
    • Politics
    • Economy
    • Sports
    • Arts&Culture
    • Health
    • Miscellaneous
    • Technology
    • Environment
  • Articles
    • Opinion
    • Analysis
    • Blog
    • Features
  • Videos
    • NewsFeed
    • Video Features
    • Explainers
    • TV
    • Digital Series
  • Infographs
  • In Pictures
  • • LIVE
News
  • Politics
  • Economy
  • Sports
  • Arts&Culture
  • Health
  • Miscellaneous
  • Technology
  • Environment
Articles
  • Opinion
  • Analysis
  • Blog
  • Features
Videos
  • NewsFeed
  • Video Features
  • Explainers
  • TV
  • Digital Series
Infographs
In Pictures
  • Africa
  • Asia
  • Asia-Pacific
  • Europe
  • Latin America
  • MENA
  • Palestine
  • US & Canada
BREAKING
Al Mayadeen's correspondent: The Lebanese Army is continuing its investigations and will later announce any information that does not affect the confidentiality of the investigation
Al Mayadeen's correspondent: It has not yet been determined whether the detainees belong to ISIS or another organization
Al Mayadeen's correspondent: Around 10 people of different nationalities, including Lebanese nationals, were detained
Al Mayadeen's correspondent: The Lebanese army arrested a number of people in the Matn area of Mount Lebanon with possession it has not disclosed
Gaza Civil Defense spokesman: We have strong indications that there are martyrs, injuries, and trapped people in the Salah al-Din area
Gaza Civil Defense spokesman: Citizens should avoid Salah al-Din Street because anyone who approaches it is at risk of being directly targeted
Gaza Civil Defense spokesman: Reality is that there is a very limited retreat of the vehicles, with the occupation forces providing cover undeer fire up to Salah al-Din Street
Gaza Civil Defense spokesman: Claims that the Israeli occupation has withdrawn from areas in the neighborhoods of al-Zaytoun, al-Tuffah, and al-Shujaiya are false
Hamas: The two delegations stressed that any negotiations must lead to the achievement of our people's goals and aspirations, foremost among which is ending the war and the complete withdrawal of enemy forces
Hamas: A delegation from the Hamas leadership, led by the head of the leadership council, Mohammad Darwish, met with an Islamic Jihad delegation, headed by its Secretary-General, Ziyad al-Nakhalah

Study shows depression linked to low serotonin release: The Guardian

  • By Al Mayadeen English
  • Source: The Guardian
  • 5 Nov 2022 16:19
4 Min Read

The study which was conducted at the Imperial College of London shows that people with depression have a decreased response to the release of serotonin.

  • x
  • Study shows depression linked to low capacity for serotonin release
    Study shows depression linked to low serotonin release

A new study published in the journal Biological Psychiatry revealed that the slow capacity to release serotonin was linked to depression among people. 

The findings revive a 50-year-old debate that researchers have dubbed the serotonin hypothesis, which considers that diminished activity of serotonin pathways plays a causal role in the pathophysiology of depression. 

This particular study, which was conducted at the Imperial College of London shows, that people with depression have a decreased response to the release of serotonin.

"This is the first direct evidence that the release of serotonin is blunted in the brains of people with depression," said Prof Oliver Howes, a consultant psychiatrist based at Imperial College and King’s College London and a co-author.

"People have been debating this question for 60 years, but it’s all been based on indirect measures. So this is a really important step."

The hypothesis emerged from studies conducted on postmortem brains and blood samples that suggested low quantities of serotonin could be responsible for higher incidences of depression.

The theory further offers a plausible biological mechanism for how the principal class of antidepressant drugs, namely selective serotonin reuptake inhibitors, works effectively well.

Yet, evidence is required to support the claim that serotonin abnormalities are the principal cause of depression, and tackling this question may benefit the provision of better treatments.

Read more: How to improve your mental health? Take a break from news

This study contributes to the debate by showing how serotonin plays a crucial role via new brain imaging techniques that could unfold new ways of understanding why SSRI drugs failed to help an estimated 10% to 30% of patients.

"It’s the closest anyone has been able to get so far,” said Howes. “It’s hard to measure these transmitters in the brains of living people. We can’t put a pipette in there and take a sample. This is the closest we’re likely to come."

The study included the participation of seventeen patients with major depressive disorder or depression linked to Parkinson’s disease and 20 healthy volunteers for comparative purposes.

PET scans were conducted on participants using a radioactive tracer to determine quantities of serotonin that were released to receptors in the brain.

After participants were given a certain dose of amphetamines to stimulate serotonin release, their brains were scanned again and showed that response to the release of serotonin was slower in depressed patients. 

Prof Catherine Harmer, of the University of Oxford, who was not involved in the work, said, "It’s really noteworthy that they found evidence for lower serotonin release," adding that a few would now argue that depression is always a result of low serotonin. 

Harmer said that few in the field would say that depression was the outcome of low serotonin, but the results were "very much in line with the idea that serotonin may play an important role."

Others rather expressed skepticism. Eiko Fried, a clinical psychologist at the University of Leiden, said, "The conclusions the authors draw are not proportional to the evidence presented."

"The statistical analyses are inconsistent and do not … establish ‘clear evidence’ for the serotonin theory of depression."

On her part, Joanna Moncrieff, professor of psychiatry at University College London, said, “This study does not provide convincing evidence that a serotonin abnormality is the cause or mechanism underlying depression, or one of the causes or mechanisms."

Howes said the results further studies to fully back the results and determine whether any serotonin differences cause depression or arise from the condition.

"It’s important because whilst current treatments do help a lot of people they don’t work for everyone,” he said.

"For large numbers of people the first treatment doesn’t work and some people can’t find any treatment that helps."

Read more: Anti-depressants change the structure of the brain: Study

  • serotonin
  • Mental Health
  • depression

Most Read

Hezbollah SG reveals war details on Al Mayadeen for the first time

Hezbollah SG reveals war details on Al Mayadeen for the first time

  • Politics
  • 8 Jul 2025
Major ambush in Gaza kills 6 Israeli troops, injures dozens

Major ambush in Gaza kills 5 Israeli troops, injures 14

  • Politics
  • 8 Jul 2025
Israeli soldiers are seen in Beit Hanoun ahead of an operation by the al-Qassam Brigades, undated (Al-Qassam Brigades Military Media)

'Israel' on blast as media exposes report discrepancies in Gaza ambush

  • Palestine
  • 8 Jul 2025
Yemen Navy sinks ETERNITY C ship, shares footage of operation

Yemen Navy sinks ETERNITY C ship, shares footage of operation

  • Politics
  • 9 Jul 2025

Coverage

All
The Ummah's Martyrs

Read Next

All
The Freedom Flotilla ship Handala as it departs for Gaza, where it aims to break the maritime blockade at a port in Syracuse, Sicily in southern Italy on July 13, 2025. (AFP)
Palestine

Freedom Flotilla's Handala departs Sicily in bid to break Gaza siege

The container ship CMA CGM Laperouse, left, docks at the Georgia Ports Authority's Port of Savannah, Sept. 29, 2021, in Savannah, Ga (AP)
Politics

US shipbuilding woes deepen as tariffs, outdated policies backfire

Gaza war raises ethical questions for ex-Obama, Biden officials
Politics

Mercenary firm tied to Gaza war crimes hires Obama-Biden PR operatives

'Israel' targets children in Gaza collecting water
Palestine

'Israel' strikes Gaza kids fetching water, blames it on 'malfunction'

Al Mayadeen English

Al Mayadeen is an Arab Independent Media Satellite Channel.

All Rights Reserved

  • x
  • Privacy Policy
  • About Us
  • Contact Us
  • Authors
Android
iOS